β-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation

Activation of β-catenin has been causatively linked to the etiology of colon cancer. Conditional stabilization of this molecule in pro-T cells promotes thymocyte development without the requirement for pre-TCR signaling. We show here that activated β-catenin stalls the developmental transition from...

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Detalhes bibliográficos
Main Authors: Guo, Zhuyan, Dose, Marei, Kovalovsky, Damian, Chang, Rui, O'Neil, Jennifer, Look, A. Thomas, von Boehmer, Harald, Khazaie, Khashayarsha, Gounari, Fotini
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890819/
https://ncbi.nlm.nih.gov/pubmed/17317856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-11-059071
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