Tcf-1 and HEB cooperate to establish the epigenetic and transcription profile of CD4(+)CD8(+) thymocytes

Thymocyte development requires a complex orchestration of multiple factors. Ablating either Tcf-1 or HEB in CD4(+)CD8(+)-thymocytes elicits similar developmental outcomes including increased proliferation, decreased survival, and reduced late Tcra rearrangements. Here, we provide a mechanistic expla...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Emmanuel, Akinola Olumide, Arnovitz, Stephen, Haghi, Leila, Mathur, Priya S., Mondal, Soumi, Quandt, Jasmin, Okoreeh, Michael K., Maienschein-Cline, Mark, Khazaie, Khashayarsha, Dose, Marei, Gounari, Fotini
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867931/
https://ncbi.nlm.nih.gov/pubmed/30420627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0254-4
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