Tcf-1 and HEB cooperate to establish the epigenetic and transcription profile of CD4(+)CD8(+) thymocytes

Thymocyte development requires a complex orchestration of multiple factors. Ablating either Tcf-1 or HEB in CD4(+)CD8(+)-thymocytes elicits similar developmental outcomes including increased proliferation, decreased survival, and reduced late Tcra rearrangements. Here, we provide a mechanistic expla...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Immunol
Autori principali: Emmanuel, Akinola Olumide, Arnovitz, Stephen, Haghi, Leila, Mathur, Priya S., Mondal, Soumi, Quandt, Jasmin, Okoreeh, Michael K., Maienschein-Cline, Mark, Khazaie, Khashayarsha, Dose, Marei, Gounari, Fotini
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867931/
https://ncbi.nlm.nih.gov/pubmed/30420627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0254-4
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi