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Loss of adenomatous polyposis coli gene function disrupts thymic development
Loss of the adenomatous polyposis coli (APC) protein is a common initiating event in colon cancer. Here we show that thymocyte-specific loss of APC deregulated β-catenin signaling and suppressed Notch-dependent transcription. These events promoted the proliferation of cells of the double-negative 3...
में बचाया:
| में प्रकाशित: | Nat Immunol |
|---|---|
| मुख्य लेखकों: | , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2005
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4662936/ https://ncbi.nlm.nih.gov/pubmed/16025118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1228 |
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