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Loss of adenomatous polyposis coli gene function disrupts thymic development

Loss of the adenomatous polyposis coli (APC) protein is a common initiating event in colon cancer. Here we show that thymocyte-specific loss of APC deregulated β-catenin signaling and suppressed Notch-dependent transcription. These events promoted the proliferation of cells of the double-negative 3...

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Bibliografiske detaljer
Udgivet i:Nat Immunol
Main Authors: Gounari, Fotini, Chang, Rui, Cowan, Janet, Guo, Zhuyan, Dose, Marei, Gounaris, Elias, Khazaie, Khashayarsha
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662936/
https://ncbi.nlm.nih.gov/pubmed/16025118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1228
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