c-Myc mediates pre-TCR-induced proliferation but not developmental progression

Constitutive and cell-autonomous signals emanating from the pre-T-cell receptor (pre-TCR) promote proliferation, survival and differentiation of immature thymocytes. We show here that induction of pre-TCR signaling resulted in rapid elevation of c-Myc protein levels. Cre-mediated thymocyte-specific...

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Detalhes bibliográficos
Main Authors: Dose, Marei, Khan, Irum, Guo, Zhuyan, Kovalovsky, Damian, Krueger, Andreas, von Boehmer, Harald, Khazaie, Khashayarsha, Gounari, Fotini
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895574/
https://ncbi.nlm.nih.gov/pubmed/16788099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-02-005900
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