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Extracellular rigidity sensing by talin isoform–specific mechanical linkages

The ability of cells to adhere and sense differences in tissue stiffness is crucial for organ development and function. The central mechanisms by which adherent cells detect extracellular matrix compliance, however, are still unknown. Using two single-molecule–calibrated biosensors that allow the an...

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Pubblicato in:Nat Cell Biol
Autori principali: Austen, Katharina, Ringer, Pia, Mehlich, Alexander, Chrostek-Grashoff, Anna, Kluger, Carleen, Klingner, Christoph, Sabass, Benedikt, Zent, Roy, Rief, Matthias, Grashoff, Carsten
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662888/
https://ncbi.nlm.nih.gov/pubmed/26523364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3268
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