Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1

Prostacyclin synthase (PGIS) and microsomal prostaglandin E synthase-1 (mPGES-1) are prostaglandin (PG) terminal synthases that function downstream of inducible cyclooxygenase (COX)-2 in the PGI(2) and PGE(2) biosynthetic pathways, respectively. mPGES-1 has been shown to be involved in various COX-2...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sasaki, Yuka, Kamiyama, Shuhei, Kamiyama, Azusa, Matsumoto, Konomi, Akatsu, Moe, Nakatani, Yoshihito, Kuwata, Hiroshi, Ishikawa, Yukio, Ishii, Toshiharu, Yokoyama, Chieko, Hara, Shuntaro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661703/
https://ncbi.nlm.nih.gov/pubmed/26611322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17376
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