Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

mPGES-1 (microsomal prostaglandin E synthase-1) is a stimulus-inducible enzyme that functions downstream of COX (cyclo-oxygenase)-2 in the PGE(2) (prostaglandin E(2))-biosynthesis pathway. Although COX-2-derived PGE(2) is known to play a role in the development of various tumours, the involvement of...

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Detalhes bibliográficos
Main Authors: Kamei, Daisuke, Murakami, Makoto, Sasaki, Yuka, Nakatani, Yoshihito, Majima, Masataka, Ishikawa, Yukio, Ishii, Toshiharu, Uematsu, Satoshi, Akira, Shizuo, Hara, Shuntaro, Kudo, Ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825730/
https://ncbi.nlm.nih.gov/pubmed/19845504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090045
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