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Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity

BACKGROUND AND PURPOSE: Although both microsomal prostaglandin E synthase (mPGES)-1 and cyclooxygenase (COX)-2 are critical factors in stroke injury, but the interactions between these enzymes in the ischaemic brain is still obscure. This study examines the hypothesis that mPGES-1 activity is requir...

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Autors principals: Ikeda-Matsuo, Y, Hirayama, Y, Ota, A, Uematsu, S, Akira, S, Sasaki, Y
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839275/
https://ncbi.nlm.nih.gov/pubmed/20128796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00595.x
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