A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α Subunit

Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChR) are important therapeutic candidates as well as valuable research tools. We identified a novel type II PAM, (R)-7-bromo-N-(piperidin-3-yl)benzo[b]thiophene-2-carboxamide (Br-PBTC), which both increases activation and...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Wang, Jingyi, Kuryatov, Alexander, Jin, Zhuang, Norleans, Jack, Kamenecka, Theodore M., Kenny, Paul J., Lindstrom, Jon
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661399/
https://ncbi.nlm.nih.gov/pubmed/26432642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676551
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