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A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair
Cells have evolved complex biochemical pathways for DNA interstrand crosslink (ICL) removal. Despite the chemotherapeutic importance of ICL repair, there have been few attempts to identify which mechanistic DNA repair inhibitor actually inhibits ICL repair. To identify such compounds, a new and robu...
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| Pubblicato in: | Bioorg Med Chem |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4661111/ https://ncbi.nlm.nih.gov/pubmed/26462050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.09.045 |
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