Thermal stability of purified and reconstituted CFTR in a locked open channel conformation

CFTR is unique among ABC transporters as the only one functioning as an ion channel and from a human health perspective because mutations in its gene cause cystic fibrosis. Although considerable advances have been made towards understanding CFTR’s mechanism of action and the impact of mutations, the...

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Vydáno v:Protein Expr Purif
Hlavní autoři: Aleksandrov, Luba A., Jensen, Timothy J., Cui, Liying, Kousouros, Joseph N., He, Lihua, Aleksandrov, Andrei A., Riordan, John R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661089/
https://ncbi.nlm.nih.gov/pubmed/26384709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2015.09.018
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