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Total synthesis of biologically active 20S-hydroxyvitamin D3

A total synthetic strategy of 20S-hydroxyvitamin D3 [20S-(OH)D3] involving modified synthesis of key intermediates 7 and 12, Grignard reaction to stereoseletively generate 20S-OH and Wittig-Horner coupling to establish D3 framework, was completed in 16 steps with an overall yield of 0.4 %. The synth...

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Detalhes bibliográficos
Publicado no:Steroids
Main Authors: Wang, Qinghui, Lin, Zongtao, Kim, Tae-Kang, Slominski, Andrzej T., Miller, Duane D., Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659745/
https://ncbi.nlm.nih.gov/pubmed/26433048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2015.09.009
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