AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition

AMP-activated protein kinase (AMPK), an important downstream effector of the tumor suppressor liver kinase 1 (LKB1) and pharmacologic target of metformin, is well known to exert a preventive and inhibitory effect on tumorigenesis; however, its role in cancer progression and metastasis has not been w...

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Publicat a:Mol Pharmacol
Autors principals: Lin, Hui, Li, Nianshuang, He, Huan, Ying, Ying, Sunkara, Shashank, Luo, Lingyu, Lv, Nonghua, Huang, Deqiang, Luo, Zhijun
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658597/
https://ncbi.nlm.nih.gov/pubmed/26424816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099549
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