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AMPK inhibits Smad3‐mediated autoinduction of TGF‐β1 in gastric cancer cells
We have previously shown that adenine monophosphate‐activated protein kinase (AMPK) regulates transforming growth factor β (TGF‐β)‐triggered Smad3 phosphorylation. Here we report that AMPK inhibits TGF‐β1 production. First, metformin reduced mRNA levels of TGF‐β1 in gastric cancer cells, in parallel...
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| Pubblicato in: | J Cell Mol Med |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7957200/ https://ncbi.nlm.nih.gov/pubmed/33538080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16308 |
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