Metformin attenuates trauma‐induced heterotopic ossification via inhibition of Bone Morphogenetic Protein signalling

AMP‐activated protein kinase (AMPK) is an intracellular sensor of energy homoeostasis that is activated under energy stress and suppressed in energy surplus. AMPK activation leads to inhibition of anabolic processes that consume ATP. Osteogenic differentiation is a process that highly demands ATP du...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Lin, Hui, Shi, Fuli, Jiang, Shanshan, Wang, Yuanyuan, Zou, Junrong, Ying, Ying, Huang, Deqiang, Luo, Lingyu, Yan, Xiaohua, Luo, Zhijun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754007/
https://ncbi.nlm.nih.gov/pubmed/33169942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16076
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