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Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells

The epithelial-to-mesenchymal transition (EMT) is the development of increased cell plasticity that occurs normally during wound healing and embryonic development and can be coopted for cancer invasion and metastasis. TGF-beta induces EMT but the mechanism is unclear. Our studies suggest Nox4, a mem...

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Bibliografiske detaljer
Main Authors: Boudreau, Howard E., Casterline, Benjamin W., Rada, Balazs, Korzeniowska, Agnieszka, Leto, Thomas L.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448829/
https://ncbi.nlm.nih.gov/pubmed/22728268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.06.016
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