Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells

BACKGROUND: Transforming growth factor-beta (TGF-β) induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis. Mechanisms involved in TGF-β-mediated EMT and cell motility are unclear. Recent studies showed that p53...

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Hlavní autoři: Boudreau, H E, Casterline, B W, Burke, D J, Leto, T L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021516/
https://ncbi.nlm.nih.gov/pubmed/24714748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.165
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