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Oxidative Stress and Response to Thymidylate Synthase-Targeted Antimetabolites
Thymidylate synthase (TYMS; EC 2.1.1.15) catalyzes the reductive methylation of 2ʹ-deoxyuridine-5ʹ-monophosphate (dUMP) by N(5),N(10)-methyhlenetetrahydrofolate, forming dTMP for the maintenance of DNA replication and repair. Inhibitors of TYMS have been widely used in the treatment of neoplastic di...
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| Publicat a: | Mol Pharmacol |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4658596/ https://ncbi.nlm.nih.gov/pubmed/26443810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099614 |
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