Leflunomide Induces Pulmonary and Hepatic CYP1A Enzymes via Aryl Hydrocarbon Receptor

Emerging evidence indicates that the aryl hydrocarbon receptor (AhR) plays a crucial role in normal physiologic homeostasis. Additionally, aberrant AhR signaling leads to several pathologic states in the lung and liver. Activation of AhR transcriptionally induces phase I (CYP1A) detoxifying enzymes....

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Vydáno v:Drug Metab Dispos
Hlavní autoři: Patel, Ananddeep, Zhang, Shaojie, Paramahamsa, Maturu, Jiang, Weiwu, Wang, Lihua, Moorthy, Bhagavatula, Shivanna, Binoy
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2015
Témata:
Short Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658494/
https://ncbi.nlm.nih.gov/pubmed/26417045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.066084
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