Aryl hydrocarbon Receptor is Necessary to Protect Fetal Human Pulmonary Microvascular Endothelial Cells against Hyperoxic Injury: Mechanistic Roles of Antioxidant Enzymes and RelB

Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. Activation of the aryl hydrocarbon receptor (AhR) protects adult and newborn mice against hyperoxic lung injury by mediating increases in the expression of phase I (cytochrome P450 (CYP) 1A) and phase...

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Udgivet i:Toxicol Appl Pharmacol
Main Authors: Zhang, Shaojie, Patel, Ananddeep, Chu, Chun, Jiang, Weiwu, Wang, Lihua, Welty, Stephen E., Moorthy, Bhagavatula, Shivanna, Binoy
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458211/
https://ncbi.nlm.nih.gov/pubmed/25831079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.03.023
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