Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway

Glycoproteins and non-glycoproteins possessing unfolded/misfolded parts in their luminal regions are cleared from the endoplasmic reticulum (ER) by ER-associated degradation (ERAD)-L with distinct mechanisms. Two-step mannose trimming from Man(9)GlcNAc(2) is crucial in the ERAD-L of glycoproteins. W...

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Gepubliceerd in:J Cell Biol
Hoofdauteurs: Ninagawa, Satoshi, Okada, Tetsuya, Sumitomo, Yoshiki, Horimoto, Satoshi, Sugimoto, Takehiro, Ishikawa, Tokiro, Takeda, Shunichi, Yamamoto, Takashi, Suzuki, Tadashi, Kamiya, Yukiko, Kato, Koichi, Mori, Kazutoshi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2015
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657166/
https://ncbi.nlm.nih.gov/pubmed/26572623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201504109
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