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The Crucial Role of Demannosylating Asparagine-Linked Glycans in ERADicating Misfolded Glycoproteins in the Endoplasmic Reticulum

Most membrane and secreted proteins are glycosylated on certain asparagine (N) residues in the endoplasmic reticulum (ER), which is crucial for their correct folding and function. Protein folding is a fundamentally inefficient and error-prone process that can be easily interfered by genetic mutation...

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Veröffentlicht in:Front Plant Sci
Hauptverfasser: Zhang, Jianjun, Wu, Jiarui, Liu, Linchuan, Li, Jianming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835635/
https://ncbi.nlm.nih.gov/pubmed/33510762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpls.2020.625033
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