The Unfolded Protein Response Transducer ATF6 Represents a Novel Transmembrane-type Endoplasmic Reticulum-associated Degradation Substrate Requiring Both Mannose Trimming and SEL1L Protein

Proteins misfolded in the endoplasmic reticulum (ER) are cleared by the ubiquitin-dependent proteasome system in the cytosol, a series of events collectively termed ER-associated degradation (ERAD). It was previously shown that SEL1L, a partner protein of the E3 ubiquitin ligase HRD1, is required fo...

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Detalhes bibliográficos
Main Authors: Horimoto, Satoshi, Ninagawa, Satoshi, Okada, Tetsuya, Koba, Hibiki, Sugimoto, Takehiro, Kamiya, Yukiko, Kato, Koichi, Takeda, Shunichi, Mori, Kazutoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814748/
https://ncbi.nlm.nih.gov/pubmed/24043630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476010
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