EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD

Sequential mannose trimming of N-glycan (Man(9)GlcNAc(2) -> Man(8)GlcNAc(2) -> Man(7)GlcNAc(2)) facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). Our gene knockout experiments in human HCT116 cells have revealed that EDEM2 is required for the first s...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: George, Ginto, Ninagawa, Satoshi, Yagi, Hirokazu, Saito, Taiki, Ishikawa, Tokiro, Sakuma, Tetsushi, Yamamoto, Takashi, Imami, Koshi, Ishihama, Yasushi, Kato, Koichi, Okada, Tetsuya, Mori, Kazutoshi
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039678/
https://ncbi.nlm.nih.gov/pubmed/32065582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53455
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