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EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD
Sequential mannose trimming of N-glycan (Man(9)GlcNAc(2) -> Man(8)GlcNAc(2) -> Man(7)GlcNAc(2)) facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). Our gene knockout experiments in human HCT116 cells have revealed that EDEM2 is required for the first s...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7039678/ https://ncbi.nlm.nih.gov/pubmed/32065582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53455 |
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