Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes

Second-generation antipsychotics are widely used to medicate patients with schizophrenia, but may cause metabolic side effects such as diabetes, which has been considered to result from obesity-associated insulin resistance. Olanzapine is particularly well known for this effect. However, clinical st...

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Pubblicato in:eLife
Autori principali: Ninagawa, Satoshi, Tada, Seiichiro, Okumura, Masaki, Inoguchi, Kenta, Kinoshita, Misaki, Kanemura, Shingo, Imami, Koshi, Umezawa, Hajime, Ishikawa, Tokiro, Mackin, Robert B, Torii, Seiji, Ishihama, Yasushi, Inaba, Kenji, Anazawa, Takayuki, Nagamine, Takahiko, Mori, Kazutoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7671685/
https://ncbi.nlm.nih.gov/pubmed/33198886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60970
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