JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M

AIM: To identify non-quinazoline kinase inhibitors effective against drug resistant mutants of epidermal growth factor receptor (EGFR). METHODS: A kinase inhibitor library was subjected to screening for specific inhibition pertaining to the in vitro kinase activation of EGFR with the gatekeeper muta...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:World J Biol Chem
Prif Awduron: Nishiya, Naoyuki, Sakamoto, Yasumitsu, Oku, Yusuke, Nonaka, Takamasa, Uehara, Yoshimasa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Baishideng Publishing Group Inc 2015
Pynciau:
Basic Study
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657120/
https://ncbi.nlm.nih.gov/pubmed/26629323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4331/wjbc.v6.i4.409
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