Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival()

Evolutionary Action analyses of The Cancer Gene Atlas data sets show that many specific p53 missense and gain-of-function mutations are selectively overrepresented and functional in high-grade serous ovarian cancer (HGSC). As homozygous alleles, p53 mutants are differentially associated with specifi...

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Pubblicato in:Neoplasia
Autori principali: Mullany, Lisa K., Wong, Kwong-Kwok, Marciano, David C., Katsonis, Panagiotis, King-Crane, Erin R., Ren, Yi Athena, Lichtarge, Olivier, Richards, JoAnne S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656807/
https://ncbi.nlm.nih.gov/pubmed/26585234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.10.003
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