P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis

BACKGROUND: P16 DNA methylation is well known to be the most frequent event in cancer development. It has been reported that genetic inactivation of P16 drives cancer growth and metastasis, however, whether P16 DNA methylation is truly a driver in cancer metastasis remains unknown. RESULTS: A P16-sp...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Cui, Chenghua, Gan, Ying, Gu, Liankun, Wilson, James, Liu, Zhaojun, Zhang, Baozhen, Deng, Dajun
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656189/
https://ncbi.nlm.nih.gov/pubmed/26592237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0819-6
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