The p16-Specific Reactivation and Inhibition of Cell Migration Through Demethylation of CpG Islands by Engineered Transcription Factors

Methylation of CpG islands inactivates transcription of tumor suppressor genes including p16 (CDKN2A). Inhibitors of DNA methylation and histone deacylation are recognized as useful cancer therapeutic chemicals through reactivation of the expression of methylated genes. However, these inhibitors are...

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Hlavní autoři: Zhang, Baozhen, Xiang, Shengyan, Zhong, Qiming, Yin, Yanru, Gu, Liankun, Deng, Dajun
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2012
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472532/
https://ncbi.nlm.nih.gov/pubmed/22738793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.070
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