C-terminal in Sp1-like artificial zinc-finger proteins plays crucial roles in determining their DNA binding affinity

BACKGROUND: It is well known that the C-terminal zinc-finger-3 in transcription factor Sp1 contributes more than the N-terminal zinc-finger-1 in determining Sp1’s DNA binding capacity. Sp1-like artificial poly-zinc-finger proteins (ZFPs) are powerful biotechnological tools for gene-specific recogniz...

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Detalles Bibliográficos
Publicado en:BMC Biotechnol
Main Authors: Zhang, Baozhen, Xiang, Shengyan, Yin, Yanru, Gu, Liankun, Deng, Dajun
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219604/
https://ncbi.nlm.nih.gov/pubmed/24289163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-13-106
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