The p16-Specific Reactivation and Inhibition of Cell Migration Through Demethylation of CpG Islands by Engineered Transcription Factors

Methylation of CpG islands inactivates transcription of tumor suppressor genes including p16 (CDKN2A). Inhibitors of DNA methylation and histone deacylation are recognized as useful cancer therapeutic chemicals through reactivation of the expression of methylated genes. However, these inhibitors are...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhang, Baozhen, Xiang, Shengyan, Zhong, Qiming, Yin, Yanru, Gu, Liankun, Deng, Dajun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Mary Ann Liebert, Inc. 2012
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472532/
https://ncbi.nlm.nih.gov/pubmed/22738793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.070
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