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P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis
BACKGROUND: P16 DNA methylation is well known to be the most frequent event in cancer development. It has been reported that genetic inactivation of P16 drives cancer growth and metastasis, however, whether P16 DNA methylation is truly a driver in cancer metastasis remains unknown. RESULTS: A P16-sp...
Shranjeno v:
| izdano v: | Genome Biol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4656189/ https://ncbi.nlm.nih.gov/pubmed/26592237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0819-6 |
| Oznake: |
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