DNA hydroxymethylation increases the susceptibility of reactivation of methylated P16 alleles in cancer cells

It is well established that 5-methylcytosine (5mC) in genomic DNA of mammalian cells can be oxidized into 5-hydroxymethylcytosine (5hmC) and other derivates by DNA dioxygenase TETs. While conversion of 5mC to 5hmC plays an important role in active DNA demethylation through further oxidation steps, a...

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Vydáno v:Epigenetics
Hlavní autoři: Li, Paiyun, Gan, Ying, Qin, Sisi, Han, Xiao, Cui, Chenghua, Liu, Zhaojun, Zhou, Jing, Gu, Liankun, Lu, Zhe-Ming, Zhang, Baozhen, Deng, Dajun
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574387/
https://ncbi.nlm.nih.gov/pubmed/31790633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1700004
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