DNA hydroxymethylation increases the susceptibility of reactivation of methylated P16 alleles in cancer cells

It is well established that 5-methylcytosine (5mC) in genomic DNA of mammalian cells can be oxidized into 5-hydroxymethylcytosine (5hmC) and other derivates by DNA dioxygenase TETs. While conversion of 5mC to 5hmC plays an important role in active DNA demethylation through further oxidation steps, a...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Epigenetics
Auteurs principaux: Li, Paiyun, Gan, Ying, Qin, Sisi, Han, Xiao, Cui, Chenghua, Liu, Zhaojun, Zhou, Jing, Gu, Liankun, Lu, Zhe-Ming, Zhang, Baozhen, Deng, Dajun
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2019
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574387/
https://ncbi.nlm.nih.gov/pubmed/31790633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1700004
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires