Homeostatic Maintenance of Allele-Specific p16 Methylation in Cancer Cells Accompanied by Dynamic Focal Methylation and Hydroxymethylation

AIM: p16 Methylation frequently occurs in carcinogenesis. While it has been hypothesized that the p16 methylation states are dynamically maintained in cancer cells, direct evidence supporting this hypothesis has not been available until now. METHODS: A fusion cell model was established which reprogr...

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Bibliographic Details
Main Authors: Qin, Sisi, Li, Qiang, Zhou, Jing, Liu, Zhao-jun, Su, Na, Wilson, James, Lu, Zhe-ming, Deng, Dajun
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020935/
https://ncbi.nlm.nih.gov/pubmed/24828678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097785
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