Homeostatic Maintenance of Allele-Specific p16 Methylation in Cancer Cells Accompanied by Dynamic Focal Methylation and Hydroxymethylation

AIM: p16 Methylation frequently occurs in carcinogenesis. While it has been hypothesized that the p16 methylation states are dynamically maintained in cancer cells, direct evidence supporting this hypothesis has not been available until now. METHODS: A fusion cell model was established which reprogr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Qin, Sisi, Li, Qiang, Zhou, Jing, Liu, Zhao-jun, Su, Na, Wilson, James, Lu, Zhe-ming, Deng, Dajun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020935/
https://ncbi.nlm.nih.gov/pubmed/24828678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097785
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