DNA hydroxymethylation increases the susceptibility of reactivation of methylated P16 alleles in cancer cells

It is well established that 5-methylcytosine (5mC) in genomic DNA of mammalian cells can be oxidized into 5-hydroxymethylcytosine (5hmC) and other derivates by DNA dioxygenase TETs. While conversion of 5mC to 5hmC plays an important role in active DNA demethylation through further oxidation steps, a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Li, Paiyun, Gan, Ying, Qin, Sisi, Han, Xiao, Cui, Chenghua, Liu, Zhaojun, Zhou, Jing, Gu, Liankun, Lu, Zhe-Ming, Zhang, Baozhen, Deng, Dajun
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574387/
https://ncbi.nlm.nih.gov/pubmed/31790633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1700004
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados