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PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence

Promyelocytic leukemia protein (PML) nuclear bodies (NBs) recruit multiple partners, including p53 and many of its regulators. NBs are believed to facilitate several posttranslational modifications and are key regulators of senescence. PML, the organizer of NBs, is expressed as a number of splice va...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ivanschitz, Lisa, Takahashi, Yuki, Jollivet, Florence, Ayrault, Olivier, Le Bras, Morgane, de Thé, Hugues
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655504/
https://ncbi.nlm.nih.gov/pubmed/26578773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507540112
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