Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.

The PML protein, identified first as part of the oncogenic PML-RARalpha chimera in acute promyelocytic leukemia (APL), concentrates within discrete subnuclear structures, corresponding to some types of nuclear bodies. These structures are disrupted in APL cells, and retinoic acid (RA) can trigger th...

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Bibliographic Details
Main Authors: Müller, S, Matunis, M J, Dejean, A
Format: Artigo
Language:Inglês
Published: 1998
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170358/
https://ncbi.nlm.nih.gov/pubmed/9427741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.1.61
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