Loading...

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.

The PML protein, identified first as part of the oncogenic PML-RARalpha chimera in acute promyelocytic leukemia (APL), concentrates within discrete subnuclear structures, corresponding to some types of nuclear bodies. These structures are disrupted in APL cells, and retinoic acid (RA) can trigger th...

Full description

Saved in:
Bibliographic Details
Main Authors: Müller, S, Matunis, M J, Dejean, A
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170358/
https://ncbi.nlm.nih.gov/pubmed/9427741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.1.61
Tags: Add Tag
No Tags, Be the first to tag this record!