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Arkadia, a Novel SUMO-Targeted Ubiquitin Ligase Involved in PML Degradation

Arkadia is a RING domain E3 ubiquitin ligase that activates the transforming growth factor β (TGF-β) pathway by inducing degradation of the inhibitor SnoN/Ski. Here we show that Arkadia contains three successive SUMO-interacting motifs (SIMs) that mediate noncovalent interaction with poly-SUMO2. We...

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書誌詳細
主要な著者: Erker, Yigit, Neyret-Kahn, Helene, Seeler, Jacob S., Dejean, Anne, Atfi, Azeddine, Levy, Laurence
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2013
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648077/
https://ncbi.nlm.nih.gov/pubmed/23530056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01019-12
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