Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

Modification with SUMO regulates many eukaryotic proteins. Down-regulation of sumoylated forms of proteins involves either their desumoylation, and hence recycling of the unmodified form, or their proteolytic targeting by ubiquitin ligases that recognize their SUMO modification (termed STUbL or ULS)...

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Publicado no:Nat Commun
Main Authors: Sriramachandran, Annie M., Meyer-Teschendorf, Katrin, Pabst, Stefan, Ulrich, Helle D., Gehring, Niels H., Hofmann, Kay, Praefcke, Gerrit J. K., Dohmen, R. Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695498/
https://ncbi.nlm.nih.gov/pubmed/31417085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11549-3
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