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Arkadia, a Novel SUMO-Targeted Ubiquitin Ligase Involved in PML Degradation
Arkadia is a RING domain E3 ubiquitin ligase that activates the transforming growth factor β (TGF-β) pathway by inducing degradation of the inhibitor SnoN/Ski. Here we show that Arkadia contains three successive SUMO-interacting motifs (SIMs) that mediate noncovalent interaction with poly-SUMO2. We...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3648077/ https://ncbi.nlm.nih.gov/pubmed/23530056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01019-12 |
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