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PML is a ROS sensor activating p53 upon oxidative stress
Promyelocytic leukemia (PML) nuclear bodies (NBs) recruit partner proteins, including p53 and its regulators, thereby controlling their abundance or function. Investigating arsenic sensitivity of acute promyelocytic leukemia, we proposed that PML oxidation promotes NB biogenesis. However, physiologi...
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| Publié dans: | J Exp Med |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5679165/ https://ncbi.nlm.nih.gov/pubmed/28931625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160301 |
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