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PML is a ROS sensor activating p53 upon oxidative stress

Promyelocytic leukemia (PML) nuclear bodies (NBs) recruit partner proteins, including p53 and its regulators, thereby controlling their abundance or function. Investigating arsenic sensitivity of acute promyelocytic leukemia, we proposed that PML oxidation promotes NB biogenesis. However, physiologi...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Niwa-Kawakita, Michiko, Ferhi, Omar, Soilihi, Hassane, Le Bras, Morgane, Lallemand-Breitenbach, Valérie, de Thé, Hugues
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679165/
https://ncbi.nlm.nih.gov/pubmed/28931625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160301
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