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PML is a ROS sensor activating p53 upon oxidative stress
Promyelocytic leukemia (PML) nuclear bodies (NBs) recruit partner proteins, including p53 and its regulators, thereby controlling their abundance or function. Investigating arsenic sensitivity of acute promyelocytic leukemia, we proposed that PML oxidation promotes NB biogenesis. However, physiologi...
שמור ב:
| הוצא לאור ב: | J Exp Med |
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| Main Authors: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
The Rockefeller University Press
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5679165/ https://ncbi.nlm.nih.gov/pubmed/28931625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160301 |
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