Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting

Differential modulation of kappa opioid receptor (KOR) signaling has been a proposed strategy for developing therapies for drug addiction and depression by either activating or blocking this receptor. Hence, there have been significant efforts to generate ligands with diverse pharmacological propert...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Zhou, Lei, Stahl, Edward L., Lovell, Kimberly M., Frankowski, Kevin J., Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655192/
https://ncbi.nlm.nih.gov/pubmed/26160155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.07.001
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