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Crossreactive αβ T cell receptors are the predominant targets of thymocyte negative selection
The precise impact of thymic positive and negative selection on the T cell receptor (TCR) repertoire remains controversial. Here, we used unbiased, high-throughput cloning and retroviral expression of individual preselection TCRs to provide a direct assessment of these processes at the clonal level...
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| 發表在: | Immunity |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4654978/ https://ncbi.nlm.nih.gov/pubmed/26522985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.09.009 |
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