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Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
In the thymus, the T lymphocyte repertoire is purged of a substantial portion of highly self-reactive cells. This negative selection process relies on the strength of TCR-signaling in response to self-peptide-MHC complexes, both in the cortex and medulla regions. However, whether cytokine-signaling...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6923358/ https://ncbi.nlm.nih.gov/pubmed/31857584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13456-z |
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