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Crossreactive αβ T cell receptors are the predominant targets of thymocyte negative selection

The precise impact of thymic positive and negative selection on the T cell receptor (TCR) repertoire remains controversial. Here, we used unbiased, high-throughput cloning and retroviral expression of individual preselection TCRs to provide a direct assessment of these processes at the clonal level...

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Bibliografische gegevens
Gepubliceerd in:Immunity
Hoofdauteurs: McDonald, Benjamin D., Bunker, Jeffrey J., Erickson, Steven A., Oh-Hora, Masatsugu, Bendelac, Albert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654978/
https://ncbi.nlm.nih.gov/pubmed/26522985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.09.009
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