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Elevated T Cell Receptor Signaling Identifies a Thymic Precursor to the TCRαβ(+)CD4(−)CD8β(−) Intraepithelial Lymphocyte Lineage
The origin and developmental pathway of intestinal T cell receptor αβ(+) CD4(−)CD8β(−) intraepithelial lymphocytes (unconventional iIELs), a major population of innate-like resident cytolytic T cells, have remained elusive. By cloning and expressing several TCRs isolated from unconventional iIELs, w...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4188477/ https://ncbi.nlm.nih.gov/pubmed/25131532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.07.008 |
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