Igs as Substrates for Transglutaminase 2: Implications for Autoantibody Production in Celiac Disease

Autoantibodies specific for the enzyme transglutaminase 2 (TG2) are a hallmark of the gluten-sensitive enteropathy celiac disease. Production of the Abs is strictly dependent on exposure to dietary gluten proteins, thus raising the question how a foreign Ag (gluten) can induce an autoimmune response...

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Foilsithe in:J Immunol
Main Authors: Iversen, Rasmus, Fleur du Pré, M., Di Niro, Roberto, Sollid, Ludvig M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: AAI 2015
Ábhair:
Autoimmunity
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654229/
https://ncbi.nlm.nih.gov/pubmed/26503953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501363
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