The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs

Double-stranded RNA (dsRNA)-activated protein kinase (PKR) is an important component of the innate immune system that presents a crucial first line of defense against viral infection. PKR has a modular architecture comprising a regulatory N-terminal dsRNA binding domain and a C-terminal kinase domai...

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Publicado en:J Biol Chem
Autores principales: Sunita, S., Schwartz, Samantha L., Conn, Graeme L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653674/
https://ncbi.nlm.nih.gov/pubmed/26432638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679738
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